| 基底细胞癌中p53,bcl—2及bax蛋白的表达 |
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| 引用本文： | 颜兰香,陈明亮.基底细胞癌中p53,bcl—2及bax蛋白的表达[J].湖南医科大学学报,1999,24(2):179-180. |
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| 作者姓名： | 颜兰香 陈明亮 |
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| 摘 要： | 采用免疫组化法，检测了３２例基义细胞癌中ｐ５３蛋白，ｂａｘ蛋白和ｂｃｌ－２蛋白的表达。结果显示：ｐ５３蛋白阳性表达１３例，ｂｃｌ－２蛋白阳性表达２６例，ｂａｘ蛋白阳性性表达９例；提示基底细胞癌的发生，发展可能与细胞凋亡受抑制有关。
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| 关 键 词： | 基底细胞癌 pt3基因 bcl－2基因 bax蛋白 |
Expression of bcl-2, bax and p53 protein in the basal cell carcinoma] |
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| L Yan,M Chen,G Yu.Expression of bcl-2, bax and p53 protein in the basal cell carcinoma][J].Bulletin of Hunan Medical University,1999,24(2):179-180. |
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| Authors: | L Yan M Chen G Yu |
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| Institution: | Department of Dermatology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011. |
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| Abstract: | The expression of bcl-2, bax and p53 protein was studied in the basal cell carcinoma with 32 patients by immunohistochemical method. The results showed that bcl-2 protein was positive in 26 patients (81.2%), bax protein was positive in 9 patients(28.1%), and p53 protein was positive in 13 patients (40.6%); there is a negative correlation between the expression of bcl-2 and bax protein(P < 0.05). These findings suggest that apoptosis is suppressed which might cause the production of basal cell carcinoma. |
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