卡马西平对癫痫患者SCE频率的影响其与叶酸的关系

检测１５例单服卡马西平（ＣＢＺ）及１５例服用ＣＢＺ加叶酸（ＦＡ）的癫痫患者外周血淋巴细胞姊妹染色单体交换（ＳＣＥ）频率，同时用放射免疫法测定其血清叶酸值，并与未服药癫痫对照组及正常对照组进行比较。结果显示，单服ＣＢＺ组的ＳＣＥ频率较服用ＣＢＺ加ＦＡ组及对照组高，其血清ＦＡ值下降。提示ＣＢＺ可引起癫痫患者ＳＣＥ频率升高、血清叶酸值减少，补充叶酸可有效防止ＣＢＺ引起的染色体ＤＮＡ损伤。

Relationship between the effect of carbamazepine on SCE frequencies and folic acid in epileptic patients]

Peripheral blood lymphocyte sister chromatid exchange(SCE) frequencies, serum folic acid(FA) levels were examined in 15 epileptic patients treated with carbamazepine(CBZ), and another 15 epileptic patients treated with CBZ and folic acid(FA). The untreated epileptic patients and the healthy subjects served as control. The results showed that SCE frequencies were significantly higher in CBZ Group, compared with CBZ plus FA Group and control(P < 0.01). Serum FA levels were lower in CBZ Group compared with healthy control(P < 0.01). It suggests that CBZ can induce the increase of SCE frequencies. Supplementation with FA may effectively prevent chromosome DNA damage induced by CBZ.