| 鼠视网膜的免疫原性 |
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| 引用本文： | 高玲,姜德咏.鼠视网膜的免疫原性[J].湖南医科大学学报,1999,24(3):215-218. |
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| 作者姓名： | 高玲 姜德咏 |
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| 摘 要： | 为探讨视网膜的免疫原性，选择ＤＢＡ／２鼠（ＭＨＣ为Ｈ－２＾ｄ）为供体，Ｃ５７ＢＬ／６（ＭＨＣ为Ｈ－２＾ｂ）或ＢＡＬＢ／Ｃ鼠（ＭＨＣ为Ｈ－２＾ｄ）为受体，把ＤＢＡ／２鼠的半个视网膜移植于受体鼠的皮下，２周后检测迟发型超敏反应（ＤＴＨ）和细胞毒性Ｔ淋巴细胞（ＣＴＬ）。结果示移植组的迟发型超敏反应（ＤＴＨ）和细胞介导的细胞毒效应（ＣＴＬ）均低于阳性对照ＤＢＡ／２鼠脾细胞组，高于阴性对照假手术组。提示ＤＢ
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| 关 键 词： | 视网膜 小鼠 免疫原性 视网膜移植 |
Immunogenicity of retina in mice] |
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| L Gao,D Jiang.Immunogenicity of retina in mice][J].Bulletin of Hunan Medical University,1999,24(3):215-218. |
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| Authors: | L Gao D Jiang |
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| Institution: | Department of Ophthalmology, Second Affiliated Hospital, Hunan Medical University, Changsha 410011. |
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| Abstract: | OBJECTIVE: To evaluate the immunogenicity of retina. METHODS: DBA/2 mice (MHCH-2d) were used as donors, C57BL/6 mice (MHC H-2d) or BALB/C mice (MHC H-2d) as recipients. Half retina of DBA/2 mouse was transplanted subcutaneously to a C57BL/6 or BALB/C mouse. The delayed-type hypersensitivity (DTH) and specific killing rate of cytotoxic T lymphocyte(CTL) were detected two weeks later. RESULTS: The results of DTH and specific killing rate of CTL in the retina of DBA/2 mice were significantly lower than the positive group(P < 0.01), but significantly higher than the negative group(P < 0.01). CONCLUSION: MHC Class I and Class II antigen and minor histocompatibility complex antigen(Minor HC) are expressed in the retina of the DBA/2 mouse, which stimulates immune system of recipient to produce weak cellular immune response. It is suggested that the retina has weak immunogenicity. |
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