慢性肾功能衰竭患者血浆脂蛋白a的变化与纤溶活性的关系

测定５０例一肾功能衰竭（ＣＲＦ）患者血浆脂蛋白（ａ）〖ＬＰ（ａ）〗与组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制物（ＰＡＩ）活性，并与６０名健康人对照。结果表明：ＣＲＦ患者血资浆Ｌｐ（ａ）浓度明显升高，ｔ－ＰＡ活性明显降低，Ｌｐ（ａ）与血浆尿素氮水平，２４ｈ尿蛋白量及尿蛋白浓度成正相关；与ｔ－ＰＡ活性成上关。提示肾功能对血浆Ｌｐ（ａ）浓度起一定的调节作用，ＬＰ（ａ）水平的升高可能与纤溶损伤有关。

Plasma Lp (a) levels and correlation of Lp (a) with fibrinolysis activation in chronic renal failure]

Plasma Lp (a) concentration and activation of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1) were determined in 50 patients with chronic renal failure (CRF) and in 50 healthy subjects. The results demonstrated that plasma concentration of Lp(a) was significantly higher and plasma t-PA activation was significantly lower in CRF patients than in healthy subjects. With multivariate analyses, plasma Lp(a) concentration was positively correlated with the total amount of 24 h uric protein, plasma BUN and uric protein concentration. Moreover, a negative significant correlation between plasma Lp(a) levels and t-PA activation was observed. Plasma Lp(a) levels did not show a correlation to PAI-1 activation. It is indicated that renal function may contribute to moderate plasma Lp(a) concentration and elevated Lp(a) levels may be related with fibrinolytic impairment.