Oxidative decarboxylation of naproxen. |
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| Authors: | F Boscá R Martínez-Má?ez M A Miranda J Primo J Soto L Va?ó |
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| Affiliation: | Departamento de Química, Universidad Politécnica de Valencia, Spain. |
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| Abstract: | The decarboxylation of naproxen (1H) and its salt (1-) was achieved by means of chemical [Ce(IV) or S2O8(2-)] and electrochemical oxidation. The product patterns were compatible with mechanisms involving single-electron transfer from the pi-system or the carboxylate moiety. The results are discussed in connection with the involvement of electron-transfer processes in the reported phototoxicity of naproxen. |
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