| 旋毛虫感染过程中小鼠T淋巴细胞亚群的变化 |
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| 引用本文： | 于文杰 连建安. 旋毛虫感染过程中小鼠T淋巴细胞亚群的变化[J]. 中国寄生虫学与寄生虫病杂志, 1989, 7(2): 94-96 |
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| 作者姓名： | 于文杰 连建安 |
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| 作者单位： | 白求恩医科大学寄生虫学教研室(于文杰)，白求恩医科大学寄生虫学教研室(连建安) |
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| 摘 要： | 应用酸性α醋酸萘酯酶(ANAE)胞浆标记法观察实验感染旋毛虫小鼠外周血T淋巴细胞及其亚群的变化。结果表明感染后d_3淋巴细胞和T淋巴细胞绝对数平行地增多,于d_(14)达高峰,d_(60)仍高于正常水平。而斑块颗粒型细胞(辅助性T细胞,T_h)和分散颗粒型细胞(抑制性T细胞,T_a)呈反向变化,前者减少,后者增多,T_h/T_a比值降低,表明旋毛虫感染过程中宿主免疫功能受抑制。
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| 关 键 词： | 旋毛虫 T细胞 ANAE法 |
Changes in populations of T lymphocytes in mice infected with Trichinella spiralis |
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| W J Yu,J A Lian. Changes in populations of T lymphocytes in mice infected with Trichinella spiralis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1989, 7(2): 94-96 |
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| Authors: | W J Yu J A Lian |
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| Abstract: | Acid alpha-naphthyl acetate esterase (ANAE), a cytoplasmic marker was used to identify the T lymphocytes and their subpopulations in peripheral blood of mice experimentally infected with T. spiralis. The results showed that the absolute number of lymphocytes and T lymphocytes increased in parallel on d3 after infection, reaching the peak on d14, and remaining above normal level on d60. The spotted granular ANAE positive cells (Helper T cells, Th) were decreasing and the scattered granular ANAE positive cells (suppressor T cells, Ts) were increasing, leading to a lowering of the Th/Ts ratio which was most marked on d14 and returned to normal on d60. The depression of host immune function during T. spiralis infection might be related to the lowering of Th/Ts ratio. |
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