产妇与新生儿血清甲状腺激素水平的相关性研究

目的　探讨产妇血清促甲状腺激素 (TSH)水平与其新生儿脐血TSH水平之间的关系。方法　应用免疫放射分析 (IRMA)法测定了 5 0 0例缺碘地区产妇及其新生儿 (研究组 )血清TSH水平 ,同时选择 10 0例非缺碘地区产妇及其新生儿作为对照组。结果　 (1)研究组产妇TSH均值为 (5 .2 5±2 .43)mU/L ,对照组为 (4.6 9± 1.34 )mU/L。研究组新生儿TSH均值为 (6 .83± 4.71)mU/L ,对照组为(5 .32± 3.0 2 )mU/L。 (2 )两组产妇及其新生儿TSH水平呈显著正相关。 (3)两组产妇TSH水平和其游离三碘甲腺原氨酸 (T3 )水平呈显著负相关。结论　监测产妇的TSH水平可评估其新生儿的碘营养状况。

A Correlative Study on the Thyroid Stimulating Hormone Levels between Pregnant Women and Their Newborns

OBJECTIVE: The correlation between serum thyroid stimulating hormone (TSH) levels in pregnant women and their neonatal cord blood was explored. METHODS: With immunoradiometric assay (IRMA) technique, the serum TSH levels of 500 pregnant women and the cord blood TSH levels in the iodine deficiency areas (study group) were tested, while the TSH levels of 100 normal pregnant women and their newborns in iodine sufficient areas (control group) were compared. RESULTS: (1) In pregnant women, the mean serum TSH level in study group was significantly higher than that of control (5.25 +/- 2.43) mU/L VS (4.69 +/- 1.34) mU/L, P < 0.01]. In newborns, the mean cord blood TSH level in study group was significantly higher than that of control (6.83 +/- 4.71) mU/L VS (5.32 +/- 3.02) mU/L, P < 0.001]. (2) The serum TSH levels in pregnant women were positively correlated with the cord blood TSH levels of their newborns in both groups. (3) The serum TSH levels of pregnant women was negatively correlated with their free triiodothy-ronine levels. CONCLUSION: The iodine nutrition status of newborns could be evaluated by monitoring the TSH levels of pregnant women.