Liver procollagen prolyl hydroxylase in Opisthorchis viverrini infected hamsters after praziquantel administration |
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Authors: | Nongporn Hutadilok Witaya Thamavit E. Suchart Upatham Pintip Ruenwongsa |
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Affiliation: | 1. Department of Biochemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand;2. Department of Pathobiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand;3. Department of Biology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand |
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Abstract: | Infection of hamsters by the human liver fluke Opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. The increase was proportional to the intensity of infection. However, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg?1 body weight, and approached normal levels two weeks after treatment. In the infected hamsters, praziquantel, at a curative dose, caused a transient increase in serum aminotransferase levels and a small but persistent rise in serum alkaline phosphatase. The drug, however, did not cause changes in these enzyme activities in the uninfected hamsters. |
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Keywords: | Praziquantel Collagen Liver procollagen prolyl hydroxylase To whom correspondence should be addressed. |
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