毛囊隆突细胞

毛囊具有不断更新的功能,提示毛囊中存在干细胞。由于周期漫长的细胞集中存在于隆突部位,所以隆突细胞被认为是表皮组织的干细胞。现已成功证实隆突细胞具有干细胞的一系列特性:高增殖能力、多向分化能力等。基于技术的飞速发展,人们对隆突细胞的表面标志、分离技术以及基因表达都有了较深刻的认识。

Hair Follicle Bulge Cells

Hair follicles reconstitute themselves though the hair cycle,suggesting the presence of stem cells.Slow-cycling cells were found in the bulge area and were considered as stem cells of the epidermis.Multiple studies have constantly demonstrated that bulge cells possess stem cell properties such as high proliferative capacity and multiple potencies to regenerate into not only hair follicles but also sebaceous glands and epidermis.Recently,the knowledge of the bulge cell biology is rapidly increasing along with the identification of novel cell surface markers,the ability to isolate living bulge cells,and the microarray analysis of multiple gene expression.