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| 磺脲受体1基因外显子16-3c/t多态性与格列齐特降血糖的关系 | |
| 引用本文： | 张慧娟,刘晓民,匡洪宇,孙宏,邢厚恂. 磺脲受体1基因外显子16-3c/t多态性与格列齐特降血糖的关系[J]. 中国临床药理学杂志, 2007, 23(5): 369-371 |
| 作者姓名： | 张慧娟 刘晓民 匡洪宇 孙宏 邢厚恂 |
| 作者单位： | 1. 哈尔滨医科大学,第一临床医院内分泌科,哈尔滨,150001 2. 哈尔滨医科大学,公共卫生学院,哈尔滨,150001 3. 安徽省生物医学研究所,合肥,230022 |
| 基金项目： | 黑龙江省教育厅科学技术研究项目 |
| 摘 要： | 目的研究磺脲类药物受体1(SUR1)基因多态性与格列齐特降糖疗效的关系。方法用Taqman-PCR技术检测119例2型糖尿病患者SUR1基因型,分析基因型与血糖变化的关系。结果SUR1基因16外显子-3c/t位点的突变纯合子tt基因型患者,其基线空腹胰岛素水平高于野生纯合子cc基因型患者(P<0.05)。格列齐特治疗后,各基因型空腹血糖、餐后2h血糖、糖化血红蛋白、空腹胰岛素及胰岛素抵抗指数下降幅度均无显著性差异。结论16外显子-3c/t多态性与格列齐特降糖疗效无关。 |
| 关 键 词： | 2型糖尿病 基因多态性 格列齐特 |
| 文章编号： | 1001-6821（2007）05-0369-03 |
| 修稿时间： | 2006-06-21 |
Relationship between the polymorphism of sylfonylurea receptor 1 extron 16-3c/t and decreased the blood glucose of gliclazide |
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| ZHANG Hui-juan,LIU Xiao-min,KUANG Hong-yu,SUN Hong,XING Hou-xun. Relationship between the polymorphism of sylfonylurea receptor 1 extron 16-3c/t and decreased the blood glucose of gliclazide[J]. The Chinese Journal of Clinical Pharmacology, 2007, 23(5): 369-371 | |
| Authors: | ZHANG Hui-juan LIU Xiao-min KUANG Hong-yu SUN Hong XING Hou-xun |
| Affiliation: | 1. Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China ; 2. College of Public Health, Harbin Medical University, Harbin 150001, China ;3. Institute of Biomedicine, Anhui Medical University, Hefei 230032, China |
| Abstract: | Objective To investigate the relationshipe between the polymorphism of sulfonylurea receptor 1 (SUR1) extron 16-3c/t and decreased the blood glucose of gliclazide. Methods SUR1 genotypes of 119 patients with type 2 diabetes were determined by Taqman-PCR. The association between the drug efficacy and genotypes was investigated.Results At baseline,the serum insulin of the group with tt genotype of SUR1 extron 16-3c/t was significantly higher than that of the group with cc genotype(P<0.05). After treatment extron 16-3c/t gene polymorphism was no associated with decrease of FPG, 2hPG,HbA1c,FINS and HOMA-IR (P>0.05). Conclusion Extron 16-3c/t gene polymorphism was no associated with the therapeutic efficacy of gliclazide,but related to insulin level. |
| Keywords: | type 2 diabetes gene polymorphism gliclazide |
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