| 基质金属蛋白酶与急性脑血管病 |
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| 引用本文： | 王珊,史福平,张国华. 基质金属蛋白酶与急性脑血管病[J]. 国际脑血管病杂志, 2005, 13(7): 541-544 |
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| 作者姓名： | 王珊 史福平 张国华 |
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| 作者单位： | 050000,石家庄,河北医科大学第二医院神经内科;050000,石家庄,河北医科大学第二医院神经内科;050000,石家庄,河北医科大学第二医院神经内科 |
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| 摘 要： | 基质金属蛋白酶(MMP)在脑血管基底膜的降解中起着重要作用,在病理条件下可导致血脑屏障受损,促进神经炎症反应的发生和发展。组织金属蛋白酶抑制剂(TIMP)是调节MMP活性的内源性抑制剂。MMP与TIMP平衡关系的失调与急性脑血管病的继发性脑损伤有关。人为地调控MMP与TIMP之间的平衡,有可能成为脑血管病的一条新的治疗途径。
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| 关 键 词： | 基质金属蛋白酶 组织金属蛋白酶抑制剂 急性脑血管病 |
| 修稿时间： | 2005-04-26 |
Matrix Metalloproteinase and Acute Cerebrovascular Diseases |
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| Shan Wang,Fu-Ping Shi,Guo-Hua Zhang. Matrix Metalloproteinase and Acute Cerebrovascular Diseases[J]. International Journal of Cerebrovascular Diseases, 2005, 13(7): 541-544 |
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| Authors: | Shan Wang Fu-Ping Shi Guo-Hua Zhang |
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| Abstract: | Matrix metalloproteinases (MMPs) play an important part in degrading the basal lamina. They lead to disruption of the blood-brain barrier and contribute to the occurrence and development of neuroinflammatory response in pathological settings. Tissue inhibitor of metalloproteinases (TIMPs) are endogenous inhibitors that regulate the activity of the MMPs. The disturbance of the equilibration between MMPs and TIMPs is associated with the secondary brain injury after acute cerebrovascular diseases. Artificially regulating the equilibration between MMPs and TIMPs may become a new approach in the treatment of cerebrovascular diseases. |
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