羊毛尘和皮毛作业混合尘致肺纤维化的实验研究

将羊毛尘50mg、80mg和皮毛作业混合尘50mg,经大鼠气管注入染尘。测定肺干重、全肺胶原蛋白含量,观察了病理改变。表明:羊毛尘组最初为异物炎性反应和肉芽肿损害,24个月发现肺间质轻度纤维化和纤维细胞灶,有较多的网织纤维和少量纤细胶原纤维。皮毛作业混合尘组早期为尘细胞结节;中期尘细胞结节群集;晚期以纤维细胞结节为主,少量细胞纤维性结节。作者认为,羊毛尘、皮毛混合尘可引起不同程度肺纤维化。

EXPERIMENTAL STUDY OF THE PULMONARY FIBROSIS CAUSED BY WOOL DUST AND MIXED FUR-PRODUCT DUST

Each rat of the wool dust groups was exposed to 50mg or 80mg of wool dust by single intratracheal route.Each rat of the fur-product mixed dust group was exposed to 50mg of fur-product mixed dust by the same way.Then dry lung of each rat was weighed and it collagenic protein content was measured.Histopa-thological examining results demonstrated that foreign inflammatory response and granulomatous lesion were seen in the lung of the wool dust groups at the beginning.Slight interstitial fibrosis of the lung and fibrocytic foci, many reticulin and some collagen fiber proliferation were found 24 months after the dust challenges. In the fur-product mixed dust group, dust cellular nodules were seen in the lung at the earlier stage. In the medial stage,a number of aggregated dust cellular nodules were observed,at the later stage,the lesions were mainly fibrocytic nodules and a few cellular fibrinous nodules. The result showed that pulmonary interstitial fibrosis of different degree might be caused by wool dust and fur-product mixed dust.