阴道镜下高频电灼术联合α-2a干扰素凝膏治疗尖锐湿疣疗效分析

目的探讨阴道镜下高频电灼术联合重组人干扰素α-2a治疗尖锐湿疣（CA）的效果。方法将165例CA分为3组，A组应用阴道镜下高频电灼术联合重组人干扰素α-2a；B组单纯采用阴道镜下高频电灼治疗；C组应用NS-FII型多功能光谱治疗仪联合肌注重组人干扰素α-2a。结果治疗后3-6个月A、B、C组复发率分别为0％、4．4％、65．4％：半年后人乳头瘤病毒（HPV）转阴率分别为93．5％、85．4％、43．8％，A组明显优于B组，B组明显优于C组，3组比较差异有统计学意义（P〈0．01）。结论阴道镜下高频电灼术联合重组人干扰素α-2a治疗CA可明显降低CA复发率和提高HPV转阴率。

Treatment of Condyloma Acuminata by Combined Interferon α-2a and High Frequency Electrical Burning Therapy under Vaginal Mirror

Objective To evaluate the curative effect of combined recombinant interferon α-2a and high frequency electrical burning therapy under vaginal mirror on condyloma acuminata. Methods 165 patients were randomly divided into three groups, Group A received the high frequency electrical burning therapy under vaginal mirror together with recombinant interferon α- 2a therapy. Group B received the high frequency electrical burning therapy under vaginal mirror only. Group C received the treatment of NS-FII muhifunctional spectrum device combined with muscle injected recombinant interferon α-2a. Results After 3 to 6 months of treatment, the relapse rate in Group A, B, C was 0%, 4.4% and 65.4%, respectively. After 6 months of treatment, HPV negative transformation rate in Group A, B, and C was 93.5%, 85.4% and 43,8%, respectively. The effectiveness of treatment is in the order of Group A 〉 Group B 〉 Group C （P〈0.01）, Conclusion Treatment of condyloma acuminata with combined high frequency electrical burning therapy and recombinant interferon α-2a can greatly reduce the relapse rate and the HPV transformation rate,