| The Effect of Tripterygium Wilfordii Monomer T4 on Rat Spermatid Nuclear Protein Transition |
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| 引用本文： | 费仁仁,陈晖,戴文平,刘平,陈啸梅,薛社普. The Effect of Tripterygium Wilfordii Monomer T4 on Rat Spermatid Nuclear Protein Transition[J]. 生殖与避孕(英文版), 1996, 0(1) |
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| 作者姓名： | 费仁仁 陈晖 戴文平 刘平 陈啸梅 薛社普 |
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| 作者单位： | Fei Ren-ren;Chen Hui;(Institute of Materia Medica，Chinese Academy of Medical Sciences，PekingUnion Medical College，Beijing 100050，China |
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| 摘 要： | （费仁仁）（陈晖）（戴文平）（刘平）（陈啸梅）（薛社普）ＴｈｅＥｆｆｅｃｔｏｆＴｒｉｐｔｅｒｙｇｉｕｍＷｉｌｆｏｒｄｉｉＭｏｎｏｍｅｒＴ４ｏｎＲａｔＳｐｅｒｍａｔｉｄＮｕｃｌｅａｒＰｒｏｔｅｉｎＴｒａｎｓｉｔｉｏｎ￥ＦｅｉＲｅｎ－ｒｅｎ；ＣｈｅｎＨｕ...
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The Effect of Tripterygium Wilfordii Monomer T4 on Rat Spermatid Nuclear Protein Transition |
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| Fei Ren-ren,Chen Hui,. The Effect of Tripterygium Wilfordii Monomer T4 on Rat Spermatid Nuclear Protein Transition[J]. Journal of Reproduction and Contraception, 1996, 0(1) |
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| Authors: | Fei Ren-ren Chen Hui |
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| Abstract: | Rat testis elongating spermatids and epididymal sperms were collected after 7 weeks of treatment with Tripterygium wilfordii monomer T4.Total nuclear basic protein(TNBP)was extracted from the elongating spermatid nuclei and the sperm nuclei isolated by sonication.Polyacrylamide gel electrophoresis has been used to separate the TNBP and individual proteins were quantified by scanning microdensitometry.It was found that the content of protamine was reduced and the TH(Total Histones)/RP(Rat Protamine)ratios were increased following treatment in the testis elongating spermatids, and same result was found in the epididymal sperms.These results suggest that the interruption of nuclear protein transition of testis spermatids induced by T4 might cause aberrant epididymal sperm nuclear protein and lead to infertility.The relationship between protamine and fertility was discussed. |
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| Keywords: | Tripterygium wilfordii Spermatid Protamine Antifertility |
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