| 超高效液相色谱在现代药代动力学中的应用 |
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| 引用本文： | 艾华, 王广基, 顾轶, 孙建国, 郝海平. 超高效液相色谱在现代药代动力学中的应用[J]. 中国药科大学学报, 2007, 38(4): 294-298. |
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| 作者姓名： | 艾华 王广基 顾轶 孙建国 郝海平 |
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| 作者单位： | 1.中国药科大学药物代谢与动力学研究中心 |
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| 基金项目： | 国家高技术研究发展计划(863计划);江苏省自然科学基金 |
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| 摘 要： | 以小颗粒填料(粒径小于2μm)和超高压系统(压力大于105kPa)为特征的超高效液相色谱(UPLC)是液相色谱领域的新热点之一,它能够提供更加高效和快速的色谱系统。本文介绍了UPLC的原理、优点及其目前存在的局限性,综述了UPLC及其联用技术在现代药代动力学中的应用及其前景。
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| 关 键 词： | 超高效液相色谱 药代动力学 体内药物分析 中药 |
| 文章编号： | 1000-5048（2007）04-0294-05 |
| 修稿时间： | 2007-04-29 |
Application of ultra performance liquid chromatography in contemporary pharmacokinetics |
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| AI Hua,WANG Guang-ji,GU Yi,SUN Jian-guo,HAO Hai-ping. Application of ultra performance liquid chromatography in contemporary pharmacokinetics[J]. Journal of China Pharmaceutical University, 2007, 38(4): 294-298 |
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| Authors: | AI Hua WANG Guang-ji GU Yi SUN Jian-guo HAO Hai-ping |
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| Affiliation: | Center of Drug Metabolism and Pharmacokinetics , China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Liquid chromatography with the column packed with small particles(sub-2-microm)and high working pressures(over 105 kPa)referred to as ultra performance liquid chromatography(UPLC),is one of the latest advances in the area of the liquid chromatographic separation.Its main advantages include high performance and fast recycling-time.The related principles,advantages and limitations concerning UPLC were discussed in this review,and the applications and the prospects of UPLC in contemporary pharmacokinetics were also introduced. |
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| Keywords: | UPLC pharmacokinetics biopharmaceutical analysis traditional Chinese medicine |
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