Two novel alkaloids from the South China Sea marine sponge Dysidea sp |
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| Authors: | Ren Shen Ma Wei Xu Tunhai Lin Xiuping Yin Hao Yang Bin Zhou Xue-Feng Yang Xian-Wen Long Lijuan Lee Kyung Jin Gao Qipin Liu Yonghong |
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| Affiliation: | Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China. |
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| Abstract: | Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiomethylated imidazolinium unit as found in dysideanin A is very rarely encountered in nature. |
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