冠心病血清C反应蛋白、纤维蛋白原、尿酸的变化及意义

目的：探讨冠心病（CHD）与血清C反应蛋白（CRP）、纤维蛋白原（FBG）及尿酸（UA）的关系。方法：分别采用终点法、比浊法检测170例不同类型的CHD患者以及58例正常人血清CRP、FBG及UA含量。结果：CHD组CRP（15．38±4．15）mg／L]、FBG（4．69±0．91）g／L]和UA（478．16±98．75）μmol／L]含量明显高于正常对照组（均P〈0．01）；CHD患者中三者的浓度均以急性心肌梗塞（AMI）组增高最明显；CRP同FBG呈正相关（r=0．793，P〈0．01）。结论：尿酸、C反应蛋白和纤维蛋白原同冠心病关系密切，C反应蛋白同纤维蛋白原呈正相关。

Changes of blood C-reactive protein,fibrinogen and blood uric acid in patients with coronary heart disease and its clinical significance

Objective： To explore the significance of change of blood C--reactive protein （CRP）, fibrinogen （FBG） and uric acid （UA） in patients with coronary heart disease （CHD）. Methods： Levels of CRP, FBG and UA in 170 CHD patients were measured and compared with those in 58 healthy controls. Results： The levels of CRP （15.38± 4.15） mg/L], FBG （4. 69±0. 91） g/L] and UA （478.16±98.75） μmol/L] were significantly higher in CHD group than those in healthy control group （P〈0.01）, and were greatly increased in AMI group compared with those of other pattern CHD cases. There was a positive correlation between CRP and FBG （r=0. 793, P〈0.01）. Conclusion： Levels of uric acid, C--reactive protein and fibrinogen are correlated with coronary heart disease. C--reactive protein is positive correlate with fibrinogen.