Cyclooxygenase-2 Expression in Colorectal Adenomas |
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| Authors: | Takanobu Sato Keigo Yoshinaga Satoshi Okabe Takuya Okawa Masayuki Enomoto Touichirou Takizawa Kenichi Sugihara |
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| Institution: | (1) Departments of Digestive Surgery and Surgical Pathology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan |
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| Abstract: | PURPOSE: Cyclooxygenase-2 is an important target for nonsteroidal anti-inflammatory drugs in suppressing colorectal tumorigenesis. To evaluate the role of cyclooxygenase-2 in sporadic colorectal adenoma, we correlated cyclooxygenase-2 expression in adenomas with other adenoma characteristics.
METHODS: Cyclooxygenase-2 expression was evaluated immunohistochemically in 95 endoscopically resected colorectal adenomas.
RESULTS: Cyclooxygenase-2 was expressed mainly in the cytoplasm of adenoma cells, where it was seen in 74 percent (70/95) of adenomas. Expression was related significantly to grade of dysplasia (P < 0.001) and tumor size (P = 0.028). Multivariate logistic regression analysis showed cyclooxygenase-2 expression in adenoma cells to be independently associated with grade of dysplasia (P = 0.001).
CONCLUSION: Observed associations suggest that cyclooxygenase-2 plays an important role in progression of the adenoma-to-carcinoma sequence. |
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| Keywords: | Colorectal carcinoma Colorectal adenoma Cyclooxygenase-2 Immunohistochemistry Dysplasia Carcinogenesis |
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