Sex-associated differences in cold-induced UCP1 synthesis in rodent brown adipose tissue |
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Authors: | Santiago Quevedo Pilar Roca Catalina Picó A Palou |
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Institution: | (1) Departament de Biologia Fonamental i Ciències de la Salut. Bioquímica i Biologia Molecular. Universitat de les Illes Balears. Ctra. Valldemossa km 7.5, Palma de Mallorca E-07071, Spain e-mail: dbfapo0@ps.uib.es Tel.: +34-71-173170, Fax: +34-71-173184, ES |
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Abstract: | The effects of acute and chronic acclimation to cold on uncoupling protein 1 (UCP1) levels, as well as on GDP-binding to
mitochondria, cytochrome c oxidase activity and mitochondrial protein concentration in brown adipose tissue (BAT) of intact male and female rats have
been analyzed. Results reveal that females rats are more sensitive to cold because their threshold temperature for the thermogenic
response is set at a higher value (around 22°C) than that of males (around 18°C), hence leading to differences in BAT UCP1
levels between the sexes at different environmental temperatures. In vitro experiments showed that steroid hormones, β-estradiol,
estrone and progesterone, can reduce norepinephrine-induced UCP1 synthesis in brown adipocytes differentiated in primary culture.
Thus the different sex-associated response of cold-induced thermogenesis in rats does not appear to be explained by a direct
action of sex steroids upon the adipocyte, implying that other factors in the thermogenic regulatory system must be involved.
Received: 23 March 1998 / Received after revision: 20 May 1998 / Accepted: 21 May 1998 |
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Keywords: | Brown adipocytes β -Estradiol Thermogenesis Uncoupling protein 1 (UCP1) |
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