| 用聚类—矩阵和法评价不同产地丹参提取物相关活性 |
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| 引用本文： | 李敏,孙虹,林佳,邢东明,杜力军.用聚类—矩阵和法评价不同产地丹参提取物相关活性[J].世界科学技术-中医药现代化,2002,4(1):33-35, 71-72. |
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| 作者姓名： | 李敏 孙虹 林佳 邢东明 杜力军 |
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| 作者单位： | 中国医学科学院中国协和医科大学药用植物研究所 北京 100094;中国医学科学院中国协和医科大学药用植物研究所 北京 100094;中国医学科学院中国协和医科大学药用植物研究所 北京 100094;清华大学生物科学与技术系药物药理学实验室 北京 100084;清华大学生物科学与技术系药物药理学实验室 北京 100084 |
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| 基金项目： | 国家自然科学基金重点项目(39730500) |
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| 摘 要： | 目的:对不同产地丹参有效部位进行药效学比较并进行评价。方法:对8个不同产地丹参含丹参素及含丹参酮成分进行了ADP诱导的血小板聚集实验、凝血酶原时间的测定及MDA的测定,对实验结果进行聚类分析和综合药效评价。结果:8种丹参的两种提取物均具有抗血小板聚集,延长凝血酶原时间及降低MDA的作用。结论:就上述活性而言,山西产丹参野生及栽培药效近似且较优于其他产地,四川中江栽培、山东野生、河南栽培药效近似,优劣居中;陕西安康野生和河南栽培相对较差。
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| 关 键 词： | 丹参 药效学 聚类分析 矩阵和法 |
| 收稿时间： | 2001/7/10 0:00:00 |
| 修稿时间： | 2001/12/21 0:00:00 |
Comparison of Effects of Salvia Miltiorrhiza Bge. fromDifferent Habitats by Cluster Analysis and Matrix Sum |
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| Li Min,Sun Hong,Lin Ji,Xing Dongming and Du Lijun.Comparison of Effects of Salvia Miltiorrhiza Bge. fromDifferent Habitats by Cluster Analysis and Matrix Sum[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2002,4(1):33-35, 71-72. |
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| Authors: | Li Min Sun Hong Lin Ji Xing Dongming and Du Lijun |
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| Institution: | Institute of Medicinal Plant, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100094;Lab. of Pharmacy & Pharmacology, Department of Biological Sciences and Biotechnolog, Tsinghua University, Beijing 100084 |
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| Abstract: | Objective: To compare the total effects of Salvia miltiorrhiza Bge. from different localities. Methods: ADP-induced platelet aggregation and thrombogen time and MDA in rats' brain in vitro have been determined, and cluster analysis and comprehensive evaluation method have also been used to evaluate the total effects of Salvia miltiorrhiza Bge. Results: Active components of Salvia miltiorrhiza Bge. have inhibited ADP-induced platelet aggregation, retarded blood-plasma coagulation induced by Ca2+-cephalin and reduced the MDA in rats' brain in vitro. Conclusion: The results indicate that the wild Salvia miltiorrhiza Bge. from Shanxi province is the best one among the 8 varieties and then the planting ones in Sichuan, wild ones in Shandong and planting ones in Henan. The wild Salvia miltiorrhiza Bge. in Ankang county of Shanxi Province and in Lu county of Henan province are the worse. |
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| Keywords: | salvia miltiorrhiza Bge Pharmacodynamics cluster analysis matrix sum |
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