Progress in 5H[1]benzopyrano[4,3-d]pyrimidin-5-amine series: 2-methoxy derivatives effective as antiplatelet agents with analgesic activity |
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Authors: | Bruno Olga Brullo Chiara Schenone Silvia Ranise Angelo Bondavalli Francesco Barocelli Elisabetta Tognolini Massimiliano Magnanini Francesca Ballabeni Vigilio |
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Affiliation: | Dipartimento di Scienze Farmaceutiche, Università degli Studi di Genova, Genoa, Italy. obruno@unige.it |
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Abstract: | A series of 2-methoxy-5H[1]benzopyrano[4,3-d]pyrimidin-5-amines were prepared and screened for their in vitro antiplatelet activity inducing the aggregation by ADP, arachidonic acid (AA) and collagen. In vivo experiments were performed in order to evaluate their antiphlogistic, analgesic and antipyretic activities. Title compounds showed antiplatelet activity in aggregation AA or collagen-induced, and a good analgesic activity without any gastric toxicity. Comparison with a number of analogue benzopyrano[4,3-d]pyrimidine derivatives and some SAR consideration were reported. |
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Keywords: | 2-Methoxy-5H[1]benzopyrano[4,3-d]pyrimidin-5-amines Antiplatelet activity Analgesic activity |
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