| DNA repair genotypes and phenotypes and cancer susceptibility |
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| 作者姓名： | Qingyi Wei |
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| 作者单位： | Department of Epidemiology, The University of Texas, M.D. Anderson Cancer Center |
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| 摘 要： | The role of DNA repair in the etiology of cancers has been well illustrated in several hereditary syndromes, in which an inherited defect in DNA repair and related biological processes is associated with extraordinarily high incidence of cancer. For example, patients with xeroderma pigmentosum（XP） have germline mutations in genes involved nucleotide excision repair（NER） coupled with more than 1000-fold increased risk of UV-induced skin cancers. However, such associations between inherited DNA repair defect and risk of cancer have not been apparent in the general population.
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| 关 键 词： | DNA 修复型基因 癌症 基因表达 |
DNA repair genotypes and phenotypes and cancer susceptibility |
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| Qingyi Wei.DNA repair genotypes and phenotypes and cancer susceptibility[J].Journal of Nanjing Medical University,2008,22(1):46-46. |
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| Authors: | Qingyi Wei |
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| Abstract: | The role of DNA repair in the etiology of cancers has been well illustrated in several hereditary syndromes, in which an inherited defect in DNA repair and related biological processes is associated with extraordinarily high incidence of cancer. |
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