C-反应蛋白监测指导新生儿病房抗生素应用临床研究

目的探讨C-反应蛋白（C-RP）在新生儿感染诊断中的应用价值及其在指导抗菌药物合理使用中的意义。方法154例住院新生儿按单双床号随机分为两组，研究组依据C-RP检测结果决定是否使用抗菌药物。对照组依据临床经验决定是否应用或停用抗菌药物。结果研究组使用抗菌药物58例，抗菌药物使用率为73．6％，平均使用抗菌药物4．23d；对照组使用抗菌药物72例，抗菌药物使用率为96％，平均使用6．16d。二组抗菌药物使用率和使用时间均有显著差异。结论在新生儿感染中C-RP值升高明显，对诊断新生儿感染灵敏，依赖C-RP检测可有效减少抗菌药物使用率。

Clinical Study on C-RP Supervising and Instructing the Use of Antibiotics in Neonatal Ward

Objective To study the clinical effects of C-reactive protein(C-RP) on monitoring neonatal infections and instructing on the reasonable use of antibiotics.Methods 154 cases were randomly divided into two groups by single-number and double-number.The research group was given or not given antibiotics depending on assaying C-RP.The control group was given or not given antibiotics depending on clinical experience.Results 58 cases(73.6%) were given antibiotics in the research group and the average time was 4.23 days;72 cases(96%) were given antibiotics in the control group,and the average time was 6.16 days.There was significant difference between the research group and the control group.Conclusion The results indicate that the use of assaying C-RP can increase the accuracy and sencibility of neonatal infections diagnosis,and it also can reduce the use rate of antibiotics.