Leukocyte Telomere Length Is Not Associated With BMD,Osteoporosis, or Fracture in Older Adults: Results From the Health,Aging and Body Composition Study |
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| Authors: | Jason L Sanders BA Jane A Cauley Robert M Boudreau Joseph M Zmuda Elsa S Strotmeyer Patricia L Opresko Wen‐Chi Hsueh Richard M Cawthon Rongling Li Tamara B Harris Steven B Kritchevsky Anne B Newman |
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| Affiliation: | 1. Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;2. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;3. Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;4. Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;5. Department of Medicine, University of California, San Francisco, California, USA;6. Institute of Human Genetics, University of California, San Francisco, California, USA;7. Department of Human Genetics, University of Utah, Salt Lake City, Utah, USA;8. Department of Preventive Medicine and Center for Genomics and Bioinformatics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA;9. Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda Maryland, USA;10. Department of Internal Medicine, Wake Forest University School of Medicine and J. Paul Sticht Center on Aging, Winston‐Salem, North Carolina, USA;11. Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA |
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| Abstract: | Short leukocyte telomere length (TL), low BMD, and osteoporosis have been associated with increased inflammation. Previous reports suggest an association between TL, BMD, and osteoporosis in women. We sought to verify these associations and to determine whether TL is related to fracture in a cohort of older men and women. Participants included 2750 community‐dwelling older persons from the longitudinal Health, Aging, and Body Composition Study (Health ABC) in who average leukocyte TL was measured at baseline using qPCR. We used unconditional logistic regression to determine the association of TL with prevalent fracture, Cox proportional hazards regression for the association with 7‐yr incident fracture, and mixed linear models for the association with BMD, change in BMD, and the number of incident fractures. TL was negatively correlated with age, weight, fasting insulin, and fasting glucose in men and women, and additionally, with C‐reactive protein and IL‐6 in men. TL was not associated with BMD; change in BMD over 1, 3, or 5 yr; osteoporosis; baseline fracture; or 7‐yr incident fracture, before or after adjustment for age, race, smoking, and health characteristics. TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample. |
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| Keywords: | aging BMD fracture osteoporosis telomere |
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