慢性鼻窦炎手术前后ECP、EGF、IL-6的水平变化及临床意义

目的 探究慢性鼻窦炎(CRS)鼻息肉患者鼻内镜手术(ESS)前后患者鼻腔分泌物中嗜酸性粒细胞阳离子蛋白(ECP)、表皮生长因子(EGF)、白细胞介素-6(IL-6)的变化,分析它们在术腔创伤愈合中的意义。 方法 选取行ESS的163例CRS鼻息肉患者作为研究对象,另选同期健康体检者50例作为对照组。所有患者术前及术后1、6、12周行鼻内镜检查并采集鼻腔分泌物,采用酶联免疫荧光分析技术检测鼻腔分泌物中ECP、EGF、IL-6的浓度。 结果 与对照组相比,术前ECP、EGF、IL-6含量显著升高(P<0.05)。术后1周ECP、EGF、IL-6含量显著低于对照组、术前(P<0.05)。术后6周ECP、EGF、IL-6含量显著高于对照组、术前、术后1周(P<0.05)。术后12周ECP、EGF、IL-6含量显著低于术前及术后6周(P<0.05),显著高于术后1周(P<0.05),与术前相比差异无统计学意义(P>0.05)。线性回归分析结果表明,术前ECP、EGF、IL-6含量影响术后6周和术后12周患者术腔创伤愈合情况(P<0.05)。 结论 CRS鼻息肉患者术前ECP、EEG、IL-6含量显著升高,且在术后创伤愈合过程中的动态变化与术后上皮修复过程可能有相关性,术前ECP、EEG、IL-6含量是影响鼻黏膜术后上皮修复的指标。

Changes in nasal secretion of ECP,EGF and IL-6 in patients with chronic sinusitis before and after endoscopic sinus surgery and their clinical significance

Objective To investigate changes in eosinophil cationic protein(ECP), epidermal growth factor(EGF)and interleukin-6 in nasal secretions of patients with chronic rhinosinusitis(CRS)and nasal polyps before and after endoscopic sinus surgery, analyzing their significance for postoperative wound healing. Methods A total of 163 CRS patients with nasal polyps who underwent endoscopic sinus surgery were enrolled in this study. Nasal secretions was collected 1, 6, and 12 weeks after operation. The concentrations of ECP, EGF and IL-6 were detected by enzyme-linked immunosorbent assay. Results Compared with a control group, preoperative ECP, EGF, and IL-6 levels were significantly increased in the patients(P<0.001). The levels of ECP, EGF and IL-6 at 1 week postoperative were significantly lower than those in the control group(P<0.05). The levels of ECP, EGF and IL-6 at 6 weeks postoperative were significantly higher than those in the control group, and also higher than the preoperative and 1-week postoperative levels(P<0.05). The levels of ECP, EGF and IL-6 at 12 weeks postoperative were significantly lower than the preoperative levels and 6-week postoperative levels(P<0.05), significantly higher than the 1-week postoperative levels(P<0.05), and not significantly different from the preoperative levels(P>0.05). Linear regression analysis showed that preoperative ECP, EGF and IL-6 levels affected the healing of the surgical cavity 6 weeks and 12 weeks postoperatively(P<0.05). Conclusion The levels of ECP, EEG and IL-6 were significantly increased in patients with CRS nasal polyps before operation, and the dynamic changes during postoperative wound healing may have been related to the postoperative epithelial repair process.