益气温阳活血法对轻度认知功能障碍患者干预的疗效观察

目的:观察益气温阳活血法对轻度认知功能障碍(MCI)临床干预的疗效。方法:将120例MCI患者随机分为治疗组和对照组各60例,对照组予基本知识及预防方法干预(健康教育手册及相关讲座,讲座每月1次,共6次)。治疗组在予基本知识及预防方法的基础上,同时服用益气温阳活血法制作的茶包(每日1包)。两组患者均以6个月为1个疗程。干预结束后进行简易智力状态检查(MMSE)总分及亚项评分,临床疗效总评量表(CGI)疗效评价两组患者治疗前后的变化。结果:(1)治疗组治疗后定向力较前提高(P0.05),MMSE总分及记忆力、注意力和空间构图3个亚项较治疗前明显提高(均P0.01);对照组MMSE总分、记忆力和语言能力的分值低于治疗前,且记忆力评分在治疗后明显降低。(2)两组患者比较,治疗组在总体上能够改善MCI患者的症状(P0.01),同时在记忆力、注意力和空间构图3个亚项上能够取得较好的效果(分别P0.01,P0.01,P0.05)。(3)两组患者CGI疗效比较,治疗组相比对照组在治疗MCI上能够取得较好疗效(P0.01)。(4)远期疗效:随访1年,治疗组未发生不良反应,对照组有3例MCI患者转化为痴呆。结论:益气温阳活血法能够改善MCI患者的认知障碍。

Observing Effects of the Method of Invigorating Qi and Warming Yang and Promoting Blood for Treating the Mild Cognitive Impairment

Objective:To observe the effect of invigorating qi and warming yang and promoting blood method treating mild cognitive impairment(MCI). Methods:There were 120 patient with MCI were random divided into treatment group and control group,60 patients in each group. The control group was intervened with the common knowledge education(a manual on health education and related health lecture,once a month for 6 months) while in the treatment group,patients were given tea bags containing invigorating qi and warming yang and promoting blood herbs as well as the intervention in the control group. Both groups were treated for 6 months. After the treatment,patients were scored with mini-mental state examination(MMSE) and clinical global impression(CGI) to evaluate the effect. Results:(1)In the treatment group,the orientation was improved after treatment(P<0.05),and the total MMSE score,memory,attention and space configuration were significantly improved(P<0.01);in the control group,MMSE score and language score were lower than those before treatment(P<0.05),and memory score was significantly lower than that before treatment(P<0.01).(2)Compared with the control group,there was improvement of MCI symptoms(P<0.01),and memory,attention and space configuration were also improved(P <0.01,P <0.01 and P <0.05,respectively) in the treatment group.(3) Compared with the control group,treatment group showed good effect on MCI according to CGI score(P<0.01).(4)Long term effect:After one-year follow up,there was no adverse reaction in the treatment group,but 3 patients developed into dementia in the control group. Conclusion:The method of invigorating qi and warming yang and promoting blood can relieve MCI.