头颈部鳞状细胞癌的靶向治疗研究进展

头颈部肿瘤是常见肿瘤之一,超过95%的病理类型是鳞状细胞癌,手术与放化疗结合的综合治疗方案是头颈部鳞状细胞癌(HNSCC)的主要治疗方案,但是总体生存率并不高,主要原因是肿瘤复发和/或转移;同时复发性或转移性HNSCC常无法进行手术治疗,放化疗效果也差。靶向治疗的发现为HNSCC、特别是复发性或转移性HNSCC的治疗提供了新的方法。为了进一步认识靶向治疗的临床治疗作用,就HNSCC的靶向治疗研究进展做一综述。

Targeted therapy for head and neck squamous cell carcinoma

Head and neck cancer is one of the most common tumors in the world. More than 95% of all pathological types are squamous cell carcinomas. The combination of surgery and radiotherapy and chemotherapy is the widely accepted treatment for head and neck squamous cell carcinoma(HNSCC). However, the overall survival rate is low, mainly owing to tumor recurrence and/or metastasis. Meanwhile, in recurrent or metastatic HNSCC, surgery is often difficult. Moreover, the effect of radiotherapy and chemotherapy is also poor. The discovery of targeted therapy has provided a new approach for the treatment of HNSCCs, especially those that are recurrent or metastatic. To further understand the clinical therapeutic effect of targeted therapy, this article reviews the research progress of targeted therapy for HNSCC.