| 药物基因组学与心律失常疾病的治疗 |
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| 引用本文： | 申音,邓婕,宋洪涛. 药物基因组学与心律失常疾病的治疗[J]. 中国临床药理学与治疗学, 2010, 15(11): 1315-1320 |
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| 作者姓名： | 申音 邓婕 宋洪涛 |
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| 作者单位： | 1. 南京军区福州总医院药学科,福建,350025,福州;沈阳药科大学药学院,沈阳110016,辽宁
2. 南京军区福州总医院药学科,福建,350025,福州 |
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| 摘 要： | 抗心律失常药物的治疗剂量和中毒剂量非常接近,而个体的差异易引起药物的不良反应。为此研究抗心律失常药物的药物基因组学来正确地引导药物的使用,以期达到理想的治疗效果并减少毒副作用。本文就近年来抗心律失常药物基因组学的研究进展作一综述。
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| 关 键 词： | 药物基因组学 抗心律失常药物 基因多态性 药物代谢酶 |
Pharmacogenomics and therapy in arrhythmic disease |
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| SHEN Ying,DENG Jie,SONG Hong-tao. Pharmacogenomics and therapy in arrhythmic disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(11): 1315-1320 |
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| Authors: | SHEN Ying DENG Jie SONG Hong-tao |
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| Affiliation: | 1Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fujian 350025,Fuzhou,China;2College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,Liaoning,China |
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| Abstract: | Therapeutic dose and toxic dose about antiarrhythmic drugs are extremely near,and the individual difference is easy to induce drug adverse reaction.Studies on pharmacogenomics of antiarrhythmic drugs have correctly conducted the use of drugs in order to achieve desirable treatment and effectiveness and reduce side effects.This article presents an overview of the current research progress of pharmacogenomics of antiarrhythmic drugs. |
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| Keywords: | Pharmacogenomics Antiarrhythmic drugs Genomic polymorphism Drug metabolizing enzyme |
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