唐古特大黄多糖组分1对电离辐射损伤小鼠免疫功能的保护作用

目的：探讨唐古特大黄多糖组分1（RTP1）对电离辐射损伤小鼠免疫功能的防护作用。方法：采用昆明种小鼠,随机分为5组：正常对照组（normal control,NC）、辐射对照组（irradiation control,IC）、RTP1低剂量组（200 mg/kg）、中剂量组（400 mg/kg）和高剂量组（800 mg/kg）。采用灌胃给药方式,连续14 d。NC组和IC组则给予等量的生理盐水。第14天除NC组外,各组小鼠均接受2.0 Gy/只60Coγ射线照射1次,照射后24 h,对小鼠的非特异性免疫功能、体液免疫功能及细胞免疫功能指标进行检测。结果：与IC组比较,RTP1组小鼠的胸腺、脾脏指数、碳廓清指数和腹腔巨噬细胞吞噬功能以及脾淋巴细胞增殖能力、血清溶血素生成值以及NK细胞活性均明显增加,与IC组比较差异有统计学意义（P〈0.05或P〈0.01）。结论：RTP1对辐射所致的小鼠免疫功能损伤具有一定的防护作用。

Purified fraction 1 of polysaccharide extracted from Rheum tanguticum prevents irradiation-induced immune damage in mice

AIM:To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum on irradiation-induced immune damage in mice. METHODS:Kunming mice were randomly divided into five groups:normal group(NC),irradiation control group(IC),RTP1 low dose group(200 mg/kg),middle dose group(400 mg/kg) and high dose group(800 mg/kg).The mice in RTP1 group were poured through gastic route by RTP1 for 14 d,the mice in NC and IC group were given by 0.9% sodium chloride solution through the ...