Role of ghrelin in cognitive impairment of hypertensive elders with chronic psychological distress |
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| Authors: | Zhang Yushun Fan Fenling Tian Hongyan Feng Jun Ma Xiancang Liu Yamin Hu Zhi Zhang Junbo Ma Yexin |
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| Institution: | 1. Department of Cardiology, Tongji, Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China;2. Department of Cardiovascular Medicine, First Affiliated Hospital, Medical, College, Xi''an Jiaotong University, Xi''an 710061, China;3. Department of Psychology and Psychiatry, First Affiliated Hospital, Medical, College, Xi''an Jiaotong University, Xi''an 710061, China;1. Institute on Aging, 3575 Geary Boulevard, San Francisco, CA 94118, USA;2. Assessment & Psychotherapy, 1330 Lincoln Avenue, Suite 110B, San Rafael, CA 94901, USA;1. Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, University of Granada, Center of Biomedical Research, Laboratory 123, Avenida del Conocimiento s/n, 18016 Armilla, Granada, Spain;2. Unit of Metabolism and Paediatricc Research, Maimonides Institute of Biomedical Research and Unit of Pediatric Endocrinology, Reina Sofia University Hospital, Avenida Menéndez Pidal s/n, 14004 Córdoba, Spain;3. Unit of Investigation in Nutrition, Growth, and Human Development of Galicia, Pediatric Department, Clinic University Hospital of Santiago, University of Santiago de Compostela, Travesía da Choupana, s/n, 15706 Santiago de Compostela, Galicia, Spain |
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| Abstract: | ObjectiveTo investigate ghrelin level change in combination with psychological stress in the hypertensive old people with cognitive impairment and to explore its effect as well as possible mechanism.MethodsThe study population of 300 elders was divided into 2 groups, 148 with hypertension and 152 non-hypertension, who were screened for psychological distress and cognition function, and had blood drawn to measure plasma levels of ghrelin and total cortisol on the same day.ResultsThe rates of anxiety and cognitive impairment were higher in the hypertension elders, which were negatively correlated with plasma ghrelin level, resulted from chronic cortisol response to anxiety.ConclusionChronic plasma cortisol increase to long-term anxiety leads a reduce in ghrelin level which then adversely affects blood pressure and cognitive function in old people. So measuring ghrelin of elders may be a diagnostic tool to predict cognitive development and ghrelin may be a selective antihypertensive medicine for cognitive impairment elders with or without chronic psychological stress. |
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| Keywords: | Ghrelin Hypertension Cognitive impairment Psychological stress Elder |
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