水飞蓟宾联合二甲双胍与熊去氧胆酸治疗非酒精性脂肪性肝炎的对比

目的：观察水飞蓟宾联合二甲双胍治疗非酒精性脂肪性肝炎的疗效。方法：106例非酒精性脂肪性肝炎患者,随机分为治疗组（n=53）及对照组（n=53）。治疗组在控制饮食、适当运动基础上给于水飞蓟宾联合二甲双胍治疗;对照组在控制饮食、适当运动基础上给予熊去氧胆酸治疗。全部病例均连续治疗12周。结果：治疗组总有效率,丙氨酸转氨酸（ALT）、天氡氨酸转氨酶（AST）、血糖、三酰甘油（TG）、总胆固醇（TC）下降幅度均优于对照组,差异有统计学意义（P〈0.01）。结论：应用水飞蓟宾联合二甲双胍治疗非酒精性脂肪性肝炎有效,值得临床应用。

Metformin in Combined with Silibinin in the Treatment of Non-Alcoholic Steatohepatitis

Objective：This study was to investigate the effect of metformin combined with silibinin in the treatment of non-alcoholic steatohepatitis（NASH）.Methods： One hundred and six NASH patients were randomized either into the treatment group（n=53） or the control group（n=53）.Treatment group was administered the control diet,adequate exercise,and metformin in combined with silibinin treatment;while the control group was administered the control diet,adequate exercise,and ursodeoxycholic acid treatment.All patients were treated continuously for 12 weeks.Results：The total effective rate,the serum alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,glucose,triglyceride（TG）,cholesterol（TC） decline of treatment group were better than the control group（P0.01）.Conclusions：Metformin in combination with silibinin is effect on treating NASH.