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Hyper-CVAD/MA+G-CSF对淋巴瘤患者造血干细胞动员作用的研究
引用本文:陈均法,郑智茵,沈建平,沈一平,周郁鸿.Hyper-CVAD/MA+G-CSF对淋巴瘤患者造血干细胞动员作用的研究[J].中国临床药理学与治疗学,2010,15(12):1410-1413.
作者姓名:陈均法  郑智茵  沈建平  沈一平  周郁鸿
作者单位:浙江中医药大学附属第一医院血液科,浙江杭州310006
摘    要:目的:探讨Hyper-CVAD/MA中的MA(甲氨喋呤+阿糖胞苷)+粒细胞集落刺激因子(G-CSF)方案动员恶性淋巴瘤患者造血干细胞的有效性。方法:25例侵袭性非霍奇金淋巴瘤(NHL)患者随机分为两组,分别采用环磷酰胺+G-CSF方案(对照组)和Hyper-CVAD/MA+G-CSF方案(研究组)动员造血干细胞,观察动员效果、安全性。结果:研究组都1次采集成功,比对照组明显缩短采集次数(P〈0.01);研究组和对照组采集的CD34+细胞总数分别为(5.45±4.63)×106/kg、(3.04±0.74)×106/kg,差异变化相近(P〉0.05);两组感染发生率相仿(P〉0.05);两组血小板减少发生率无明显差异(P〉0.05)。结论:Hyper-CVAD/MA+G-CSF方案动员恶性淋巴瘤患者造血干细胞安全、有效、易于操作、又可起到移植前体内净化的作用。

关 键 词:淋巴瘤  Hyper-CVAD/MA方案  造血干细胞

Effects of hemopoietic stem cell mobilized by Hyper-CVAD/MA+GCSF on lymphoma patients
CHEN Jun-fa,ZHENG Zhi-yin,SHEN Jian-ping,SHEN Yi-ping,ZHOU Yu-hong.Effects of hemopoietic stem cell mobilized by Hyper-CVAD/MA+GCSF on lymphoma patients[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2010,15(12):1410-1413.
Authors:CHEN Jun-fa  ZHENG Zhi-yin  SHEN Jian-ping  SHEN Yi-ping  ZHOU Yu-hong
Institution:Department of Hematology,the First Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine,Hangzhou 310006,Zhejiang,China
Abstract:AIM:To investigate the clinical effects of hemopoietic stem cell mobilized by Hyper-CVAD/MA(methopterin+cytarabine)+granulocyte colony-stimulating factor(G-CSF) regimen on lymphoma patients. METHODS:25 patients with aggressive non-Hodgkin lymphoma(NHL) were randomly divided into two groups,which were separately applied with cyclophosphamide+G-CSF regimen(Control group) and Hyper-CVAD/MA+G-CSF regimen(Study group) to mobilize hemopoietic stem cells.And then mobilization and safety were detected.RESULTS:The data in the study group was successfully collected on the first try,the times of collection in the study group was significant reduced compared to that of the control group(P0.01);The total number of CD34+ cells in the study group and control group were separately(5.45±4.63)×106/kg and(3.04±0.74)×106/kg,which had no significant difference(P0.05);There was a similar incidence rate of infection between the two groups(P0.05);In addition,there was no significant difference in the incidence rate of thrombocytopenia between the two groups(P0.05).CONCLUSION:Hemopoietic stem cells mobilized by Hyper-CVAD/MA+G-CSF on lymphoma patients was not only safe and effective but also easy to operate.Addionally,it played the role of in vivo purging prior to transplantation.Therefore,it gained two advantages by this regimen.
Keywords:Lymphoma  Hyper-CVAD/MA regimen  Hemopoietic stem cells
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