Role of vasopressin antagonists in the management of acute decompensated heart failure |
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Authors: | Cesare Orlandi Christopher A Zimmer Mihai Gheorghiade |
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Institution: | (1) Department of Clinical Development, Otsuka Maryland Research Institute, Inc., 2440 Research Boulevard, 20850 Rockville, MD, USA |
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Abstract: | Vasopressin antagonists are a class of neurohormonal antagonists with applications in both the short-term and long-term management
of patients with acute decompensated heart failure (ADHF). The pharmacologic effects of vasopressin antagonists include changes
in fluid balance and hemodynamics that may improve symptoms and outcomes in patients hospitalized with ADHF. With chronic
therapy, vasopressin antagonists offer the potential to improve outcomes through a variety of mechanisms, including more effective
treatment of congestion, preservation or improvement of renal function, or a reduction in the use of concomitant loop diuretic
therapy. Several vasopressin antagonists are currently in advanced clinical trials for the treatment of ADHF, chronic stable
heart failure, and hyponatremia. |
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Keywords: | |
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