The incidence and course of paraneoplastic neuropathy in women with epithelial ovarian cancer |
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Authors: | Guido Cavaletti Graziella Bogliun Laura Marzorati Marta Marzola Maria Rosa Pittelli Giovanni Tredici |
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Institution: | (1) Neurology Clinic V, Ospedale S. Gerardo dei Tintori, Via Donizetti, 106, I-20052 Monza (Milan), Italy;(2) Institute of Human Anatomy, Via Mangiagalli, 31, I-20133 Milan, Italy;(3) Gynaecological Clinic V, Ospedale S, Gerardo, Via Solferino, 16, I-20052 Monza (Milan), Italy |
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Abstract: | Summary Sensorimotor polyneuropathy is the most common of the paraneoplastic syndromes involving the nervous system. Its incidence is high (more than 50%) in the patients undergoing neurophysiological investigation, and it is considered to be more frequent in subjects with lung and breast cancers. In this study we evaluated a series of 58 women with epithelial ovarian cancer at FIGO stages I and III. The aim of the study was to assess the incidence and characteristics of peripheral nerve involvement during the course of the disease both clinically and neurophysiologically. Our results suggest that in women with epithelial ovarian cancer (1) the incidence of subclinical polyneuropathy is high; (2) sensory involvement is predominant in stage I, but motor involvement is frequent in stage III; and (3) the incidence of peripheral nerve involvement increases with progression of the cancer. |
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Keywords: | Paraneoplastic neuropathy Ovarian cancer |
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