结外淋巴瘤的临床特点及治疗分析(附68例报告)

目的 探讨并评价结外淋巴瘤的临床特点及其治疗效果,为进一步提高临床疗效提供理论依据.方法 回顾性分析2012年1月至2014年3月我院收治的68例结外淋巴瘤患者的临床资料,分析患者的确诊时间、首发症状、发病部位、病理分型、临床分期和生存预后.结果 68例患者出现症状至病理检查确诊时间平均(7.63±1.25)个月.首发症状以胃肠道症状、咽喉和口鼻部症状、局部症状为主.发病部位前3位分别是胃肠道、咽和(或)扁桃体、鼻腔,分别占23.53％(16/68)、20.59％(14/68)、17.65％(12/68).病理分型:免疫分型,B细胞淋巴瘤44例,占64.71％(44/68);T细胞淋巴瘤24例,占35.29％(24/68).临床分期:Ⅰ期20例,占29.41％;Ⅱ期17例,占25.00％;Ⅲ期16例,占23.54％;Ⅳ期15例,占22.06％.68例患者经过治疗后,1年后生存率为79.42％(54/68),3年后生存率为51.47％(35/68).结论 临床对疑似结外淋巴瘤的患者应早期诊断,在诊疗过程中应该重视其临床特点以减少误诊率和漏诊率,应准确定位、分型、分期以尽早确定合理方案进行治疗,以期提高结外淋巴瘤患者的生存率.

Clinical features and treatment of extranodal lymphoma: a report of 68 cases

Objective To investigate and evaluate the clinical features and therapeutic effects of extranodal lymphoma.Methods The clinical data of 68 cases of extranodal lymphoma patients admitted to our hospital from January 2012 to March 2014 were retrospectively analyzed,including the time of diagnosis,first symptoms,location,pathological type,clinical stage and prognosis (1 years,3 years survival rate).Results The symptoms of 68 patients were pathologically diagnosed.The average time of diagnosis was (7.63 ±1.25) months.The first symptoms were gastrointestinal symptoms,throat and mouth symptoms,and local symptoms.The first three sites were gastrointestinal,pharyngeal and/or tonsil and nasal cavities,accounting for 23.53％ (16/68),20.59％ (14/68) and 17.65％ (12/68).For pathological classification,44 cases were immunophenotype B cell lymphoma,accounting for 64.71％ (44/68) and 24 cases were T cell lymphoma,accounting for 35.29％ (24/68).For clinical stage,20 cases were Ⅰ stage,accounting for 29.41％;17 cases were Ⅱ phase,accounting for 25.00％;16 cases were Ⅲ phase,accounting for 23.54％;15 cases were Ⅳ phase,accounting for 22.06％.After treatment,the patients' one year survival rate was 79.42％ (54/68),and three year survival rate was 51.47％ (35/68).Conclusion The early diagnosis of patients with suspected extranodal lymphoma should be paid attention to the clinical features in the course of diagnosis and treatment to reduce the misdiagnosis rate and missed diagnosis rate.