肠易激综合征患者的生存质量评价及其影响因素分析

目的评价肠易激综合征 irritable bowel syndrome, IBS） 病人的生存质量并分析其影响因素。方法对在消化专科门诊就诊、符合罗马Ⅲ诊断标准的73例IBS病人和78例其他功能性肠病（functional bowel diseases, FBD）患者采用肠易激综合征生存质量量表汉化版（ Chinese Irritable Bowel Syndrome-Quality Of Life Questinnaires, ChlBS-QOL），以及焦虑自评量表（Self-RatingDepressionScale，SAS）、抑郁自评量表（ Self-Rating Depression Scale, SAS）进行问卷调查，并建立病人的资料档案。结果ChIBS-QOL的总条目及各维度得分，尤其是饮食限制方面，均明显低于对照组（P均〈0．05）。将病人的性别、年龄、婚姻状态、职业、精神心理因素、文化程度、经济收入、病程、罗马Ⅲ分型，以及是否伴随功能性消化不良（FD）作为白变量，ChIBS-QOL作为因变量，进行多元逐步回归分析，筛选出精神心理因素（β=-17．729，t=-4．506，P〈0．001）和文化程度（β=3．897，t=2．688，P〈0．01）是影响ChIBS—QOL总分的主要因素。结论IBS患者的生存质量明显降低，精神心理因素和文化程度是影响其生存质量的重要因素。

Quality of life in irritable bowel syndrome patients and its influencing factors

Objective To investigate the quality of life in irritable bowel syndrome （IBS） patients and its influencing factors. Methods Seventy-three patients of IBS and seventy-eight of other functional bowel disorders （FBD） in the gastrointestinal outpatient department were diagnosed by Rome Ⅲ criteria. Chinese Irritable Bowel Syndrome-Quality Of Life Questinnaires （ChIBS-QOL） , Self-Rating Anxiety Scale （SAS） and Self-Rating Depression Scale （SDS） were self- adminstered or interview-administered to the patients. Results The ChIBS-QOL scores of eight directions and the overall score, especially in food avoidance, in IBS patients were significantly lower than those in other FBD patients （P 〈 0. 05, respectively）. Multi-factors stepwise regression analysis showed that mental status（β =-17. 729, t =- 4. 506, P 〈 0. 001 ） and the level of edueation（β = 3. 897, t = 2. 688, P 〈0.01 ） were important factors that influenced the ChIBS- QOL scores of IBS patients. Conclusion Quality of life decreases in IBS patients and its main influencing factors are mental status and the level of education.