| 桂枝茯苓混悬型无糖颗粒剂的制备工艺研究 |
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| 引用本文： | 谢冬梅,刘丛彬.桂枝茯苓混悬型无糖颗粒剂的制备工艺研究[J].安徽医药,2005,9(5):328-329. |
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| 作者姓名： | 谢冬梅 刘丛彬 |
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| 作者单位： | 1. 安徽中医学院药学院,安徽,合肥,230031
2. 合肥紫金医药科技有限公司,安徽,合肥,230088 |
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| 摘 要： | 目的筛选出最佳的桂枝茯苓颗粒剂的处方及成型工艺.方法以其成型性、溶解性为筛选指标,筛选出其处方中加入辅料的品种、配比及其最佳的成型工艺.结果桂枝茯苓提取物及药材原粉中加入1倍量的糊精,少量微晶纤维素和甜蜜素,并以10%的CMC-Na作为黏合剂为最佳处方.结论该处方的助悬性、成型性能均较好.
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| 关 键 词： | 桂枝茯苓 混悬型颗粒剂 成型工艺 颗粒剂的溶解性 |
| 修稿时间： | 2005年3月28日 |
Preparation of free-sugar suspension granule of guizhifuling |
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| XIE Dong-mei,LIU Cong-bin.Preparation of free-sugar suspension granule of guizhifuling[J].Anhui Medical and Pharmaceutical Journal,2005,9(5):328-329. |
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| Authors: | XIE Dong-mei LIU Cong-bin |
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| Abstract: | Aim To select the proper excipients for granule of guizhifuling and the preparative process.Methods With building-up properties,solubility and resistance to humid as the judgement criteria,the kinds and ratio of the excipients and preparative process were sieved out.Results The most proper excipent combination consisted of one portion of the extract of Guizhifuling and powder,1 times dextin and few microcrystalline cellulose,sodium cyclamate.Conclusion The process and its excipient combination is better than the other process of formulation. |
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| Keywords: | guizhifuling suspension granule process of formulation solution of granule |
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