Evaluation of antipyretic potential of Cleome viscosa Linn. (Capparidaceae) extract in rats |
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Authors: | Devi B Parimala Boominathan R Mandal Subhash C |
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Institution: | Division of Pharmacognosy, Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700032, India. |
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Abstract: | The antipyretic activity of a methanol extract of Cleome viscosa Linn. (CVME) was investigated for its potential on normal body temperature and yeast-induced pyrexia in albino rats. The CVME, at doses of 200, 300, and 400mg/kg BW p.o., showed significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose-dependent manner. The effect also extended upto 5h after the drug administration. The anti-pyretic effect of CVME was comparable to that of paracetamol (150mg/kg p.o.), a standard anti-pyretic agent. |
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