他汀类药物治疗非缺血性心脏病慢性心衰的临床研究

目的：探讨他汀类药物治疗非缺血性心脏病慢性心衰的疗效。方法：连续入选60例慢性非缺血性心脏病心衰患者，常规标准治疗稳定1月后随机分为阿托伐他汀20mg组（n=28例）。安慰剂组（n=32例）。测量基线水平的NYHA分级、血浆脑利钠肽（BNP）、超声心动图的左室射血分数（LVEF）、左室舒张末期内径（LVEDD）以及6分钟步行距离。分别于治疗12周和24周后重复测量上述相关参数。观察其疗效。结果：治疗12周后阿托伐他汀20mg组NYHA分级、BNP以及6min步行距离均显著改善，且优于对照组（P均〈0．05）；治疗24周后阿托伐他汀20mg组LVEDD、LVEF显著改善，且优于对照组（P均〈0．05）。结论：他汀类短期治疗能改善慢性非缺血性心脏病心衰患者的心功能、BNP及6分钟步行距离；中长期治疗有望提高LVEF、缩小LVEDD，所以他汀类有益于慢性心脏病心衰的治疗。

Clinical research of the effect of statin on non-ischemic heart failure

Objective:To investigate the efficacy of statin on non-ischemic heart failure patients.Methods:A total of 60 non-ischemic heart failure patients after standard therapy for 1 month were randomly divided into atorvastatin group(n=28) and control group(n=32).The changes on the degree of New York heart association(NYHA),brain natriuretic Peptide(BNP),left ventricular ejection fraction(LVEF),left ventricular end-diastolic dimension(LVEDD) and six-minutes walk distance(6MWD) were observed after 12 weeks and 24 weeks.Results:In atorvastatin group,NYHA stage,BNP and 6MWD significantly improved(P<0.05 all),and more than those of control group(P<0.05) after 12 weeks treatments,LVEDD significantly reduced and LVEF significantly increased(P<0.05 all) and improved more than those of control group(P<0.05) after 24 weeks treatments.Conclusion:Statin can improve heart function,BNP and 6MWD in chronic non-ischemic heart failure patients after short-term treatments and may increase LVEF and reduce LVEDD after mid-term or long-term treatments.Statin is helpful for chronic heart failure patients.