肾脏郎格罕细胞组织细胞增生症1例报道并文献复习

目的探讨肾脏郎格罕细胞组织细胞增生症（Langerhans cell histiocytosis,LCH）的临床病理特征。方法对1例肾脏LCH患者的临床病理资料进行分析并结合文献复习。结果患者年龄23岁,女性,表现为无症状性左肾肿物。腹部CT示左肾肿物,大小约4.3cm×6.1cm,考虑肾癌。行根治性左肾切除术。免疫组化显示CD1α,S-100,CD68,Lysozyme呈阳性。病理诊断为LCH。随诊3个月时未见肿瘤复发或转移。结论肾脏LCH极其罕见,确诊依赖病理学及免疫组化检查。

Report of one case of renal Langerhans cell histiocytosis and literature review

Objective To discuss the pathological and clinical characteristics of Langerhans cell histiocytosis of the kidney.Methods One case of Langerhans cell histiocytosis of the kidney was reported and related literatures were reviewed.Results A 23-year-old female presented with an asymptomatic left side renal mass.A computed tomography scan of the abdomen revealed a left renal tumor measuring 4.3 cm×6.1 cm in diameter and considered as renal cell carcinoma.The patient underwent a left radical nephrectomy.Immunohistochemistry revealed positive staining for CD1α,S-100,CD68,Lysozyme.On the basis of these results,a diagnosis of Langerhans cell histiocytosis was made.The patient has completed three months of follow up and remains disease-free at the time of this report.Conclusions Renal Langerhans cell histiocytosis is extremely rare.The diagnosis can only be made by pathological examination and immunohistochemical examination.