核基质蛋白22在非肌层浸润性膀胱癌患者预后监测中的作用

目的探讨核基质蛋白22（nuclear matrix protein 22,NMP22）在非肌层浸润性膀胱尿路上皮细胞癌患者术后复发监测中的作用。方法选取62例非肌层浸润性膀胱尿路上皮细胞癌患者,以51例成人健康体检者为对照,比较两组患者之间尿NMP22的水平有无差异;并以NMP22值〉10.0U/ml为临界点,将膀胱尿路上皮细胞癌患者分为NMP22升高组和NMP22正常组,用log-rank检验这两组患者的复发时间的差异。结果膀胱尿路上皮细胞癌患者的尿NMP22水平（平均秩和=81.18）高于对照组（平均秩和=27.61）（U=82,P〈0.001）;NMP22升高组患者的复发时间[（28.71±1.18）]月早于NMP22正常组的[（33.20±1.82）]月（χ2=4.313,P=0.038）。结论尿NMP22检查较适合于在基层医院进行膀胱尿路上皮细胞癌患者术后的随访。

The function of nuclear matrix protein 22 in the prognosis of patients with non muscle-invasive bladder cancer

Objective To study the monitoring function of nuclear matrix protein22（NMP22） for operation relapse in patients of non muscle-invasive bladder cancer.Methods 62 non muscle-invasive bladder cancer patients and 51 adults with health examination for controls were collected to compare NMP22 concentration in urine.Patients were divided into high level NMP22 group and the normal NMP22 group for with the critical point for NMP2210.0U/ml,log-rank test was used to compare the difference between the two group.Results ①The urine NMP22 concentration in patients of non muscle-invasive bladder cancer（mean rank =81.18）were higher than those of control＇s（mean rank=27.61）（U=82,P0.001）.②The relapse time of the high level NMP22 group（28.71±1.18）months were shorter than the normal group（33.20±1.82）months（χ2=4.313,P=0.038）.Conclusions Urine NMP22 was an optincal factor for follow up visit for patients with non muscle-invasive bladder cancer in rural district hospital.