舌癌组织中淋巴管密度与淋巴道转移关系的研究 |
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引用本文: | 战策,张壮.舌癌组织中淋巴管密度与淋巴道转移关系的研究[J].中国医学文摘:口腔医学,2011(1):26-29. |
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作者姓名: | 战策 张壮 |
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作者单位: | [1]同济大学附属口腔医院,上海200072 [2]四川大学华西口腔医院,四川成都610041 |
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摘 要: | 目的:研究舌癌组织中淋巴管密度(lymphatic vessel density,LVD)和舌鳞状细胞癌患者淋巴道转移的相关性。方法:舌癌样本来自138例实施舌癌切除术的患者。利用单克隆抗体D2-40进行免疫组织化学染色。对照正常组织和肿瘤组织中LVD的差异。利用Spearman相关分析评估舌癌患者的LVD和临床病理因素的联系。结果:舌癌组织中LVD明显高于正常组织(P〈0.01)。已发生转移的肿瘤组织中LVD明显高于未转移肿瘤组织(P〈0.01)。LVD与舌癌患者T分期、分级、淋巴结状态和临床分期(r=0.229,0.221,0.794,0.740)具有紧密联系。结论:LVD有规律的增长可能是舌癌发展的一个重要特征,有助于预测舌癌患者早期的淋巴转移。
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关 键 词: | 舌鳞状细胞癌 生物标记 淋巴转移 免疫组织化学 |
Investigating the relations between the lymphatic vessel density in OTSCC tissues and lymphatic metastasis |
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Authors: | ZHAN Ce ZHANG Zhuang |
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Institution: | 1.Hospital of Stomatology,Tongji University,Shanghai 200072,China;2.West China Hospital of Stomatology,Sichuan University,Chengdu 61004,China.) |
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Abstract: | Objective:To investigate the relationship of the lymphatic vessel density(LVD) in oral tongue squamous cell carcinomas(OTSCC)tissues and lymphatic metastasis of OTSCC patients.Methods: OTSCC samples were obtained from 138 patients undergoing tumor resection.Immunohistochemical staining was performed using monoclonal antibodies D2-40.LVD in normal and tumor tissue was compared.Additionally,the relations between LVD and clinicopathologic factors of OTSCC patients were evaluated by Spearman correlation analysis.Results: LVD in cancer tissues were significantly higher than those in normal tissue(P0.01).Similar results were obtained from the comparison between metastatic tumor and non-metastatic tumor(P0.01).LVD was closely related with T stage,grade,lymph node status and clinical stage(r=0.229,0.221,0.794,0.740).Conclusions: Up-regulation of LVD might be an important feature of OTSCC progression,which may exert their function and favorably predicted lymphatic dissemination for relative early stage of OTSCC patients. |
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Keywords: | Oral tongue squamous cell carcinomas Biomarkers Lymphatic metastasis Immunohistochemistry |
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