Prenylated flavonoids from the roots of Sophora flavescens with tyrosinase inhibitory activity |
| |
Authors: | Son Jong Keun Park Ji Soo Kim Jeong Ah Kim Youngsoo Chung See Ryun Lee Seung Ho |
| |
Institution: | College of Pharmacy, Yeungnam University, Kyongsan, Korea. |
| |
Abstract: | Prenylated flavonoids containing the resorcinol moiety were isolated as tyrosinase inhibitors from the roots of Sophora flavescens by activity-guided fractionation. Among the 12 compounds isolated, kuraridin, kurarinone and norkurarinol showed stronger inhibitory potencies (IC 50 = 1.1, 1.3 and 2.1 microM, respectively) than that of kojic acid (IC 50 = 11.3 microM), a well known tyrosinase inhibitor. Substitution of a lavandulyl or hydroxylavandulyl group at the C-8 position and a methoxy or hydroxy group at the C-5 position are essential for the inhibitory effect. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|