Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation |
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| Authors: | Yusuke Tanigawara Kenji Nozawa Hisatsugu Tsuda |
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| Affiliation: | (1) Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, Tokyo 160-8582, Japan;(2) Biostatics Group, Clinical Planning Department, Toyama Chemical Co., Ltd, Tokyo, Japan;(3) Research Laboratories, Toyama Chemical Co., Ltd, Toyama, Japan |
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| Abstract: | Purpose Garenoxacin, a novel des-F(6)-quinolone, possesses potent antibacterial activity against infectious pathogens in the respiratory tract. Population pharmacokinetic/pharmacodynamic (PK/PD) modeling and Monte Carlo simulations were used to optimize garenoxacin dosage regimens. |
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