白芍总苷对寻常型银屑病患者血清白介素-22的影响

目的通过对白芍总苷治疗前后寻常型银屑病患者血清中白介素(IL)-22水平的研究,探讨其治疗寻常型银屑病的作用机制。方法 2009年10月-2010年8月采用双抗体夹心酶联免疫吸附法,检测30例寻常型银屑病患者,经白芍总苷治疗前后及健康对照组20例外周血清中IL-22浓度的变化,分析其在治疗前、后与银屑病皮损面积和严重程度指数(PASI)评分的相关性。结果寻常型银屑病患者血清IL-22浓度(90.50±51.80)pg/mL]较对照组(40.10±17.20)pg/mL]升高,白芍总苷治疗后血清中IL-22水平(48.70±23.90)pg/mL]较治疗前降低(P<0.05),并与对照组差异无统计学意义(P>0.05);治疗前、后患者血清IL-22水平与PASI评分呈正相关。结论白芍总苷可能通过调节IL-22发挥治疗寻常型银屑病的作用。

Effects of Total Glucosides of Paeony on the Level of Interleukin-22 in the Serum of Patients with Psoriasis Vulgaris

Objective To analyze the therapeutic mechanism of total glucosides of paeony(TGP) through investigating the effect of TGP on the level of interleukin(IL)-22 in serum of patients with psoriasis vulgaris(PV).Methods From October 2009 to August 2010,changes of IL-22 level in the serum of 30 patients with PV and 20 healthy controls were detected by enzyme linked immunosorbent assay,and correlations between the change and Psoriasis area and severity index(PASI) score were analyzed before and after the treatment.Results IL-22 level in patients with PV (90.50 ± 51.80)pg/mL)] was significantly higher than that in the control group (40.10 ± 17.20) pg/mL](P<0.05).After treatment,the level of IL-22 (48.70 ± 23.90) pg/mL] was significantly decreased(P<0.05) in the patients,and the level was not significantly different between patients after treatment and the controls(P>0.05).Serum concentration of IL-22 showed significant positive correlations with PASI score before and after treatment.Conclusion TGP may regulate IL-22 to play a important role in treating psoriasis vulgaris.