| 原发性肝细胞癌中Survivin基因的表达及临床意义 |
| |
| 引用本文： | 张玉萍,白静,朱金玲,张春斌,罗佳滨,吕冬霞,王长山.原发性肝细胞癌中Survivin基因的表达及临床意义[J].黑龙江医药科学,2007,30(1):32-33. |
| |
| 作者姓名： | 张玉萍 白静 朱金玲 张春斌 罗佳滨 吕冬霞 王长山 |
| |
| 作者单位： | 1. 佳木斯大学基础医学院,黑龙江,佳木斯,154007
2. 哈尔滨医科大学,黑龙江,哈尔滨,150000 |
| |
| 基金项目： | 黑龙江省卫生厅资金资助项目 |
| |
| 摘 要： | 目的：Survivin是凋亡抑制蛋白中的一种，选择性地表达于恶性肿瘤组织。该文研究Survivin基因在原发性肝细胞癌（HCC）中的表达及临床意义。方法：收集肝癌细胞株SMMC-7721，40例原发性肝细胞癌组织标本及相应的癌旁组织，以半定量RT-PCR法检测SurViVinmRNA表达。结果：肝癌细胞株SMMC-7721@80％（32例）的肝癌组织表达SurvivinmRNA，而癌旁非癌组织内无一例阳性表达。结论：Survivin表达是原发性肝细胞癌中较为普遍的事件。
|
| 关 键 词： | 原发性肝细胞癌 Survivin基因 |
| 文章编号： | 1008-0104(2007)01-0032-02 |
| 修稿时间： | 2006年1月11日 |
Expression and clinical significance of Survivin in human hepatocellular carcinoma |
| |
| ZHANG Yu-ping,BAI Jing,ZHU Jin-ling,ZHANG Chun-bin,LUO Jia-bin,LV Dong-xia,WANG Chang-shan.Expression and clinical significance of Survivin in human hepatocellular carcinoma[J].Heilongjiang Medicine and Pharmacy,2007,30(1):32-33. |
| |
| Authors: | ZHANG Yu-ping BAI Jing ZHU Jin-ling ZHANG Chun-bin LUO Jia-bin LV Dong-xia WANG Chang-shan |
| |
| Abstract: | Objective:Survivin,one of the inhibitory protein of apoptosis,is selectively expressed in the tissue of malignant tumors.The present study was to investigate the role of Survivin expression in the pathogenesis of hepatocellular carcinoma(HCC).Methods:HCC cell lines SMMC-7721,forty histologically verified HCC specimens and their neighboring noncancerous tissue were obtained.Semi-quantitative RT-PCR was used to measure Survivin mRNA levels.Results:Survivin mRNA expression was detected in HCC cell lines SMMC-7721 and 32 of 40(80%) HCC tissue.In contrast,no expression of Survivin in the corresponding noncancerous tissue was detected.Conclusion:Survivin expression may play an important role in HCC carcinogenesis. |
| |
| Keywords: | hepatocellular carcinoma Survivin gene |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
