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不同手术方式联合术后放疗对外阴鳞癌预后的影响
引用本文:孙学明,张彦娜,梁东霞.不同手术方式联合术后放疗对外阴鳞癌预后的影响[J].实用癌症杂志,2011,26(4):387-390,394.
作者姓名:孙学明  张彦娜  梁东霞
作者单位:中山大学肿瘤防治中心妇科、华南肿瘤学国家重点实验室,510060
摘    要:目的对比不同手术方式联合术后放疗对外阴鳞癌的疗效,寻找理想的治疗方法。方法对1980年1月~2005年12月在中山大学肿瘤防治中心经手术治疗并确诊的150例外阴鳞癌进行回顾性分析,生存率计算采用寿命表法,预后比较采用Kaplan-Meier法。多因素预后分析采用Cox回归分析。结果对淋巴结阳性的患者,行外阴广泛切除+腹股沟淋巴结清扫和(或)盆腔淋巴结清扫术+放疗、外阴广泛切除+腹股沟肿大淋巴结切除术+放疗、外阴广泛切除术+放疗、外阴广泛切除+腹股沟淋巴结清扫和(或)盆腔淋巴结清扫术,5年生存率分别为29%、25%、17%、67%(P=0.031),5年无进展生存率分别为100%、50%、67%、83%(P=0.016),行外阴广泛切除+腹股沟淋巴结清扫和(或)盆腔淋巴结清扫术+放疗者,预后明显好于其余治疗方式患者。对术前检查未发现明显淋巴结肿大的患者,行外阴广泛切除+腹股沟淋巴结清扫和(或)盆腔淋巴结清扫术,5年生存率(84%vs.46%,P=0.010)和无进展生存率(97%vs.62%,P〈0.001)均明显高于外阴广泛切除术+放疗患者。结论对中晚期患者,应争取切除原发灶及行腹股沟淋巴结清扫,并术后辅以全量放疗,而对早期外阴癌患者,建议在切除外阴病灶的同时行腹股沟淋巴结清扫术。

关 键 词:外阴鳞癌  手术  放疗  预后

The Impect of Different Surgical Methods Combined With Postoperative Radiotherapy on Prognosis of Squamous Cell Carcinoma of the Vulva
SUN Xue-ming,ZHANG Yan-na,LIANG Dong-xia.The Impect of Different Surgical Methods Combined With Postoperative Radiotherapy on Prognosis of Squamous Cell Carcinoma of the Vulva[J].The Practical Journal of Cancer,2011,26(4):387-390,394.
Authors:SUN Xue-ming  ZHANG Yan-na  LIANG Dong-xia
Institution:SUN Xue-ming,ZHANG Yan-na,LIANG Dong-xia,et al.Department of Gynecologic Oncology,Cancer Center,Sun Yat-sen University,Guangzhou,510060
Abstract:Objective By means of comparing the therapeutic effect of different surgical methods combined with postoperative radiotherapy to squamous cell carcinoma of the vulva,to find out the best treatment method.Methods A retrospective analysis was adopted which involves 150 patients with primary squamous cell carcinoma of the vulva treated at Sun Yat-sen University Cancer Center from January 1980 to December 2005.Meanwhile,survival rate was calculated by life table method.Kaplan-Meirer method was used to evaluate ...
Keywords:Vulva squamous cell carcinoma  Surgical  Radiotherapy  Prognosis  
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