| 辛伐他汀对高胆固醇血症患者动脉弹性的影响 |
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| 引用本文： | 陈图刚,陈君柱.辛伐他汀对高胆固醇血症患者动脉弹性的影响[J].中国综合临床,2006,22(11):969-970. |
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| 作者姓名： | 陈图刚 陈君柱 |
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| 作者单位： | 1. 330003,南昌,南昌大学第四附属医院心血管内科
2. 浙江大学医学院附属第一医院心内科 |
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| 摘 要： | 目的探讨辛伐他汀对高胆固醇血症患者动脉弹性的影响。方法采用动脉弹性功能测定仪检测52例高胆固醇血症患者使用辛伐他汀前和使用4周后大动脉弹性（C1）、小动脉弹性（C2）和血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。结果用药4周后，TC和LDL-C均较用药前明显下降（均为P〈0．01），C1和C2较用药前明显升高（均为P〈0．01）。结论辛伐他汀可明显降低高胆固醇血症患者TC和LDL-C，同时显著改善动脉弹性。
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| 关 键 词： | 高胆固醇血症 辛伐他汀 动脉弹性 |
| 文章编号： | 1008-6315(2006)11-0969-02 |
| 修稿时间： | 2006年4月16日 |
Effect of simvastatin on artery elasticity in patients with hypercholesterolemia |
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| Chen Tugang,Chen Junzhu.Effect of simvastatin on artery elasticity in patients with hypercholesterolemia[J].Clinical Medicine of China,2006,22(11):969-970. |
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| Authors: | Chen Tugang Chen Junzhu |
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| Abstract: | Objective To investigate the effect of simvastatin on artery elasticity in patients with hypercholesterolemia. Methods Large arterial elasticity (C_1) and small arterial elasticity (C_2) were measured by CVProfilor TMDO-2020 Cardiovascular Profiling System.plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were tested before and 4 weeks after taking simvastatin.Results TC and LDL-C were reduced significantly (P<0.01), C_1 and C_2 were improved significantly in cases after taking sunvastatin(P<0.01) compared with those before taking drugs. Conclusion Simvastatin may reduce TC and LDL-C, and meanwhile improves artery elasticity in patients with hypercholesterolemia. |
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| Keywords: | Hypercholesterolemia Simvastatin Artery elasticity |
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