The prolonged heterogeneous implantation of mouse tumors in rats

Summary The antigenic content of Ehrlich's mouse carcinoma transplanted for more than a year on young rats was studied with the aid of cancer cell agglutination reaction (in M. M. Kapichnikov's modification). Rat species-specific antigens appear on the surface of cancer cells begining from the first generation of rats, evidently, at the expense of the rat protein adsorption. In addition to this, after 50 generations, certain mouse species-specific antigens disappear from the surface of cancer cells. Identical results are obtained in complement fixation reaction. The loss of mouse antigens is accompanied by a simultaneous decline in the growth of the tumor heterotransplants on mice.Presented by Active Member AMN SSSR N. N. Zhukov-Verezhnikov