| P2X7受体与骨代谢研究进展 |
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| 引用本文： | 李喆,马蓓,陈爱民. P2X7受体与骨代谢研究进展[J]. 第二军医大学学报, 2015, 36(7): 767-770 |
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| 作者姓名： | 李喆 马蓓 陈爱民 |
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| 作者单位： | 73018部队卫生队,上海第二军医大学基础医学实验教学中心,上海长征医院骨科 |
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| 摘 要： | P2X7受体在多种组织中表达，具有广泛的生物学效应。研究证明成骨细胞和破骨细胞都有P2X7受体表达。P2X7受体作为ATP-门控的阳离子通道在骨形成和骨吸收中发挥重要作用，本文着重对骨中表达的P2X7受体及其相关的信号通路以及P2X7受体对骨代谢的研究进展做一综述。
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| 关 键 词： | P2X7受体，骨代谢，成骨细胞，破骨细胞 |
| 收稿时间： | 2014-08-24 |
| 修稿时间： | 2015-03-10 |
Relationship between P2X7 receptor and bone metabolism: recent progress |
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| LI Zhe,MA Bei and CHEN Ai-ming. Relationship between P2X7 receptor and bone metabolism: recent progress[J]. Former Academic Journal of Second Military Medical University, 2015, 36(7): 767-770 |
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| Authors: | LI Zhe MA Bei CHEN Ai-ming |
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| Affiliation: | the Second Military Medical University,Department of Orthopedics, Changzheng Hospital |
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| Abstract: | P2X7 receptor, an ATP-gated ion channel, is widely found in various tissues and possesses multiple physiological functions. Recent reports have implicated expression of P2X7 receptor in both osteoblasts and osteoclasts, participating in both bone formation and resorption. This paper reviews the recent progresses on the influence of P2X7 receptor and its related pathways on bone metabolism. |
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| Keywords: | P2X7 receptor bone metabolism osteoblasts osteoclasts |
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